Efforts are underway to indentify the mutations in tumor cells that may give rise to cancer. Analysis of mutations in tumors from patients with head and neck squamous cell carcinoma (HNSCC) identified some familiar players (TP53, CDKN2A, PTEN, PIK3CA, HRAS ) along with some new faces (NOTCH, IRF6, TP63, CASP8, EZH2).

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